In 1982, when she was 12, her first live acting "this little kid who's on a ride with all these women and whatnot" appeared in music video "She's a Beauty". In this music video, she showed her talent in music for the first time. In 1986, she made her first appearance as an actress. She played a role as Alexis, who is the friend of Max Whiteman. In her early career, Arquette mainly played as female in different shows and named as "Eva Destruction". That might be a hard time for her to play as a female. Because no matter they are transgender women or not, they want to be real women. After that, she anounced in public that she had begun hormone treatment and gender reassignment surgery. As a male who works as a woman and want to be a woman at a very young age, it was a big progress. In her later career, she declared in public that she has changed her gender to female.
When she was 19, she played a role as a transgender woman work for porn industry in the film Last Exit to Brooklyn. Most of films she attended are independent with low budget. Her career in filming was not as ideal as what she thought at first. Arquette has played a diverse range of roles in more than 40 films so far, including including I Think I Do, Children of the Corn V: Fields of Terror, and Sometimes They Come Back... Again. Arquette also starred as different roles, including a role in a ts dating, to improve her acting skills. For example, she played as a crack addict opposite that is named Tim Roth in Jumpin' at the Boneyard. This role is totally different from other roles she played in former films. It was a great challenge for her. Due to her consistent efforts, she became one of the celebrity house-guests on the 6th season of The Surreal Life in In September 2005. That was a great honor for her. Her career was more and more successful after that. Arquette is the first transgender woman who was invited to be guest judge on the première episode of Bravo's reality show Top Design in 2007. Her career is not only limited in a certain range, she also made an appearance in Robbie Williams' music video "She's Madonna".
As a transgender woman, Arquette contracted HIV in 1987. She suffered a lot in her later life and ts date. After the struggle with HIV for many years, Alexis reinstated to his male status in 2013. Arquette died at the age of 47, on September 11, 2016. That was a great pity for her family and the whole world.